A split-face comparison of low-fluence Q-switched Nd:YAG laser plus 1550 nm fractional photothermolysis vs. Q-switched Nd: YAG monotherapy for facial melasma in Asian skin

作者：Kim Hei Sung; Kim Eun Kyung; Jung Kyoung Eun; Park Young Min; Kim Hyung Ok; Lee Jun Young^*

来源：Journal of Cosmetic and Laser Therapy, 2013, 15(3): 143-149.

DOI：10.3109/14764172.2013.769274

• Asian
• melisma
• nonablative fractional photothermolysis
• 1064 nm Q-switched Nd:YAG

Background: Melasma is a common pigmentary disorder which poses substantial therapeutic challenge. Combined therapy may be beneficial in Asians, where mixed type melasma is dominant. Objective: We sought to assess the efficacy and safety of a 1064 nm Q-switched Nd:YAG (1064 QSNY) and a nonablative 1550 nm erbium-doped fractional photothermolysis (NFP) treatment in Asian melasma. Methods: This was a split face study, in which 26 patients were treated with the 1064 QSNY (6 mm spot size, 1.2-1.4 J/cm(2) fluence) for 10 sessions at 2-week intervals to the entire face, and with the NFP (dynamic mode, pulse energy 6-8 mJ/microthermal zone (MTZ); total density 300 MTZs/cm(2)) for five sessions at 4-week intervals to the experimental side of the face. Efficacy variables were modified Melasma Area and Severity Index (mMASI), the physician%26apos;s global assessment (PhGA), and patient%26apos;s subjective global assessment (PGA). Safety was evaluated through the reporting of adverse events. Results: The percentage of subjective improvement was virtually identical on both sides. The mMASI corroborated the patients%26apos; subjective estimate, both in terms of the degree of improvement and the lack of difference between the 1064 QSNY + NFP and the 1064 QSNY treated sides. No serious side effects were reported in either side. Conclusions: Our findings do not support the hypothesis of NFP providing a substantial benefit in treating the melasma when compared with the lone treatment of the 1064 QSNY.

• 出版日期2013-6