Distinct neuronal patterns of positive and negative moral processing in psychopathy

作者：Fede Samantha J^*; Borg Jana Schaich; Nyalakanti Prashanth K; Harenski Carla L; Cope Lora M; Sinnott Armstrong Walter; Koenigs Mike; Calhoun Vince D; Kiehl Kent A^*

来源：Cognitive Affective & Behavioral Neuroscience, 2016, 16(6): 1074-1085.

DOI：10.3758/s13415-016-0454-z

• Psychopathy
• Moral
• Prosocial
• Incarceration
• fMRI
• Decision making

Psychopathy is a disorder characterized by severe and frequent moral violations in multiple domains of life. Numerous studies have shown psychopathy-related limbic brain abnormalities during moral processing; however, these studies only examined negatively valenced moral stimuli. Here, we aimed to replicate prior psychopathy research on negative moral judgments and to extend this work by examining psychopathy-related abnormalities in the processing of controversial moral stimuli and positive moral processing. Incarcerated adult males (N = 245) completed a functional magnetic resonance imaging protocol on a mobile imaging system stationed at the prison. Psychopathy was assessed using the Hare Psychopathy Checklist-Revised (PCL-R). Participants were then shown words describing three types of moral stimuli: wrong (e.g., stealing), not wrong (e.g., charity), and controversial (e.g., euthanasia). Participants rated each stimulus as either wrong or not wrong. PCL-R total scores were correlated with not wrong behavioral responses to wrong moral stimuli, and were inversely related to hemodynamic activity in the anterior cingulate cortex in the contrast of wrong > not wrong. In the controversial > noncontroversial comparison, psychopathy was inversely associated with activity in the temporal parietal junction and dorsolateral prefrontal cortex. These results indicate that psychopathy-related abnormalities are observed during the processing of complex, negative, and positive moral stimuli.

• 出版日期2016-12