Direct Synthesis of Lactams from Keto Acids, Nitriles, and H-2 by Heterogeneous Pt Catalysts

作者：Siddiki S M A H; Touchy Abeda S; Bhosale Ashvini; Toyao Takashi; Mahara Yuji; Ohyama Junya; Satsuma Atsushi; Shimizu Ken ichi^*

来源：ChemCatChem, 2018, 10(4): 789-795.

DOI：10.1002/cctc.201701355

• amination
• hydrogenation
• keto acids
• nitriles
• platinum

We report herein the first general catalytic system for the direct synthesis of N-substituted gamma- and delta-lactams by reductive amination/cyclization of keto acids (including levulinic acid) with nitriles and H-2 under mild conditions (7bar H-2, 110 degrees C, solvent free). The most effective catalyst, Pt and MoOx co-loaded TiO2 (Pt-MoOx/TiO2), shows a wide substrate scope, high turnover number (TON), and good reusability.

• 出版日期2018-2-21