Accelerated and Enhanced Bone Formation on Novel Simvastatin-Loaded Porous Titanium Oxide Surfaces

作者：Nyan Myat^*; Hao Jia; Miyahara Takayuki; Noritake Kanako; Rodriguez Reena; Kasugai Shohei

来源：Clinical Implant Dentistry and Related Research, 2014, 16(5): 675-683.

DOI：10.1111/cid.12045

• bone regeneration
• micro-arc oxidation
• osseointegration
• simvastatin
• titanium oxide

BackgroundWith increasing application of dental implants in poor-quality bones, the need for implant surfaces ensuring accelerated osseointegration and enhanced peri-implant bone regeneration is increased. %26lt;br%26gt;PurposeA study was performed to evaluate the osseointegration and bone formation on novel simvastatin-loaded porous titanium oxide surface. %26lt;br%26gt;Materials and MethodsTitanium screws were treated by micro-arc oxidation to form porous oxide surface and 25 or 50g of simvastatin was loaded. The nontreated control, micro-arc oxidized, and simvastatin-loaded titanium screws were surgically implanted into the proximal tibia of 16-week-old male Wistar rats (n=36). Peri-implant bone volume, bone-implant contact, and mineral apposition rates were measured at 2 and 4 weeks. Data were analyzed by one-way analysis of variance followed by Tukey%26apos;s post hoc test. %26lt;br%26gt;ResultsNew bone was formed directly on the implant surface in the bone marrow cavity in simvastatin-loaded groups since 2 weeks. Bone-implant contact values were significantly higher in simvastatin-loaded groups than control and micro-arc oxidized groups at both time points (p%26lt;.05). Peri-implant bone volume and mineral apposition rate of simvastatin-loaded groups were significantly higher than control and micro-arc oxidized groups at 2 weeks (p%26lt;.05). %26lt;br%26gt;ConclusionsThese data suggested that simvastatin-loaded porous titanium oxide surface provides faster osseointegration and peri-implant bone formation and it would be potentially applicable in poor-quality bones.

• 出版日期2014-10