Are oral and dental diseases linked to cancer?

作者：Meurman J H^*; Bascones Martinez A

来源：Oral Diseases, 2011, 17(8): 779-784.

DOI：10.1111/j.1601-0825.2011.01837.x

• oral cancer
• malignant disease
• microbiota
• oral hygiene

OBJECTIVE: Infection and inflammation play a role in carcinogenesis, and highly prevalent oral and dental diseases have been significantly linked to some types of cancer. This article reviews current literature in this area.
MATERIALS AND METHODS: Open literature review using the PubMed database and focused on publications from 2000 to 2010.
RESULTS: Numerous potential mechanisms are implicated in the oral disease/carcinogenesis paradigm, including infection-and inflammation-associated cell pathology and microbial carcinogen metabolism. Poor oral hygiene is associated with oral cancer, but there is also evidence of a possible link between oral or dental infections and malignancies in general.
CONCLUSION: Oral infections may trigger malignant transformation in tissues of the mouth and other organs. However, scientific evidence to date remains weak and further well-conducted studies are warranted before cancer can be properly added to the list of oral infection-related systemic diseases. Oral Diseases (2011) 17, 779-784

• 出版日期2011-11