科研之友
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摘要
Background and Aims. Several studies show that high serum C-reactive protein (CRP) levels are associated with an increased risk of diabetes, data that strongly supports a possible role for inflammation in diabetogenesis. The aim of this study was to determine whether elevated CRP levels are associated with fasting plasma glucose (FPG) and/or postload glucose levels according to the glucose tolerance status. Methods. A total of 169 healthy males and non-pregnant females aged 18-65 years were enrolled in a population-based cross-sectional study. Individuals were allocated into groups with a new diagnosis of normal glucose tolerance (NGT) (n = 82), impaired fasting glucose (IFG) (n = 54), and impaired glucose tolerance (IGT) (n = 33). Elevated CRP was defined by CRP levels >3.0 and <10.0 mg/L, IFG by FPG >= 100 and <126 mg/dL, and IGT by plasma glucose concentration 2 h postload >= 140 and <200 mg/dL. A multiple regression linear analysis adjusted by body mass index, waist circumference, and lipid profile was performed to evaluate the association between CRP levels (independent variable) with FPG and 2 h postload glucose levels (dependent variables). Results. Multivariate linear regression analysis showed a significant association between hsCRP levels with FPG (beta = 0.536; 95% CI 1.03-5.1, p = 0.005) and 2 h postload glucose (beta = 0.209; 95% CI 1.31-2.97, p = 0.01) in the IGT group, but not With FPG (beta = 0.147; 95% CI 0.55-2.0, p = 0.25) and 2 h postload glucose (beta = 0.151; 95% CI 0.83-3.2, p = 0.24) in the IFG group. Conclusions. Elevated CRP levels are associated with FPG and 2 h postload glucose in the individuals with IGT, but not in subjects with IFG or NGT.
- 出版日期2014-1
