Hybrid Nanotrimers for Dual T-1 and T-2-Weighted Magnetic Resonance Imaging

作者：Cheng, Kai; Yang, Meng; Zhang, Ruiping; Qin, Chunxia; Su, Xinhui; Cheng, Zhen^*

来源：ACS Nano, 2014, 8(10): 9884-9896.

DOI：10.1021/nn500188y

• hybrid
• nanotrimers
• dumbbell structures
• T-1/T-2-weighted magnetic resonance imaging
• positron emission tomography

Development of multifunctional nanoparticle-based probes for dual T-1- and T-2-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals via solid-state interfaces, we built hybrid heteronanostructures to combine both T-1 and T-2- weighted contrast agents together for MRI with high accuracy and reliability. The resultant hybrid heterotrimers showed high stability in physiological conditions and could induce both simultaneous positive and negative contrast enhancements in MR images. Small animal positron emission tomography imaging study revealed that the hybrid heterostructures displayed favorable biodistribution and were suitable for in vivo imaging. Their potential as dual contrast agents for T-1 and T-2-weighted MRI was further demonstrated by in vitro and in vivo imaging and relaxivity measurements.

• 出版日期2014-10
• 单位山西医科大学