An Improved Synthesis of (-)-5,11-Dideoxytetrodotoxin

作者：Adachi Masaatsu; Imazu Takuya; Isobe Minoru; Nishikawa Toshio^*

来源：Journal of Organic Chemistry, 2013, 78(4): 1699-1705.

DOI：10.1021/jo302773f

We describe an improved synthesis of (-)-5,11-dideoxytetrodotoxin from an enone, which was used for synthesis of tetrodotoxin and its analogues in this laboratory. One of the major modifications was to establish a two-step guanidinylation of trichloroacetamide of a highly functionalized intermediate, which allowed us to prepare N-15(2)-labeled 5,11-dideoxytetrodotoxin for biosynthetic investigations.

• 出版日期2013-2-15