Anti-angiogenic effect of caffeic acid on retinal neovascularization

作者：Kim Jeong Hun; Lee Byung Joo; Kim Jin Hyoung; Yu Young Suk^*; Kim Kyu Won

来源：Vascular Pharmacology, 2009, 51(4): 262-267.

DOI：10.1016/j.vph.2009.06.010

• Anti-angiogenic
• Anti-oxidant
• Caffeic acid
• Retinal neovascularization
• Reactive oxygen species
• Vascular endothelial growth factor

Pathological angiogenesis is the most common cause of vision loss at all ages including retinopathy of prematurity (ROP). diabetic retinopathy. and age-related macular degeneration. ROP is a proliferative disease of the retinal vasculature in premature infants. Herein, we demonstrated caffeic acid (CA) has the anti-angiogenic activity to retinal endothelial cells and retinal neovascularization in a mouse model of ROP. which might be related to the suppression of ROS-induced VEGF expression. CA effectively inhibited VEGF-induced proliferation of retinal endothelial cells in concentration-dependent manner. In addition, VEGF-induced migration and tube formation of retinal endothelial cells were completely inhibited This anti-angiogenic activity of CA on retinal endothelial cells was related to the anti-oxidant activity the inhibitory activity of CA to H(2)O(2)-induced reactive oxygen species production and VEGF expression. Interestingly, CA significantly suppressed retinal neovascularization in oxygen-induced retinopathy as the animal model of ROP without retinal cytotoxicity These data suggests that CA could be a potent anti-angiogenic agent for retinal neovascularization, and be applied in the treatment of other vaso-proliferative retinopathies Published by Elsevier Inc.

• 出版日期2009-10