Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells

作者：Ji Yu bin; Gao Shi yong^*

来源：Journal of Zhejiang University-Science B(Biomedicine & Biotechnology), 2008, 9(9): 701-706.

DOI：10.1631/jzus.B0820090

• arylamine N-acetyltransferases (NATs)
• apoptosis
• HepG2
• camptothecin (CAM)

Objective: To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis. Methods: NAT activity in apoptotic HepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of HepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry. Results: NAT activity was lowered in apoptotic HepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in HepG2 cells. Conclusion: NAT can inhibit apoptosis in HepG2 cells.

• 出版日期2008-9
• 单位哈尔滨商业大学