An Organocatalyzed Efficient One-pot Synthesis, Biological Evaluation, and Molecular Docking Studies of 4,4-(Arylmethylene)bis-(3-methyl-1-phenyl-1H-pyrazol-5-ols)

作者：Mahajan Pravin S; Nikam Mukesh D; Khedkar Vijay; Jha Prakash; Badadhe Pravin V; Gill Charansingh H^*

来源：Journal of Heterocyclic Chemistry, 2017, 54(2): 1109-1120.

DOI：10.1002/jhet.2681

The synthesis of 4,4-(arylmethylene)bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives catalyzed by ?-proline is a simple, versatile, and efficient method. In vitro antioxidant, anti-inflammatory, and antimicrobial activities of compounds 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j were studied. Furthermore, to rationalize the observed anti-inflammatory activity data, molecular docking study has been performed against COX-2 enzyme which revealed a good binding affinity for these molecules and could provide an insight into the various bonded and non-bonded interactions guiding their binding affinity.

• 出版日期2017-3