Diabetes-specific variables associated with quality of life changes in young diabetic people: The type 1 diabetes Registry of Turin (Italy)

作者：Trento M; Panero F; Porta M; Gruden G; Barutta F; Cerutti F; Gambino R; Perotto M; Perin P Cavallo; Bruno G^*

来源：Nutrition Metabolism and Cardiovascular Diseases, 2013, 23(10): 1031-1036.

DOI：10.1016/j.numecd.2013.01.004

• Type 1 diabetes
• Quality of life
• Registry
• Epidemiology

Background and aims: Type 1 diabetes (T1DM) affects young people during the most active years of their life. Our aim was to assess quality of life (QoL) and associated variables in a large cohort of adults with childhood-onset and adult-onset T1DM. %26lt;br%26gt;Methods: A cohort of adult patients (18 years and older) from the T1DM Registry of Turin, Italy, was recruited. Clinical characteristics and Diabetes QoL (DQOL) questionnaire were assessed by standardized procedures. %26lt;br%26gt;Results: 310 adults completed the questionnaire. Age and diabetes duration at assessment (mean +/- SD) were 32.8 +/- 7.3 years and 17.3 +/- 6.3 years, respectively. DQOL and its subscores were in the lower quartiles of their distributions, indicating a good level of QoL. However, scores were significantly higher in females than in males, particularly for the subscale of diabetes-related worries. In multivariate analysis, lower QoL was independently associated with female sex (beta = 1.07, 95% CI 1.03-1.11, p = 0.003), higher age at onset (beta = 1.03, 1.00-1.05, p = 0.009), lower schooling (beta = 1.05, 1.00-1.09, p = 0.02), higher fasting plasma glucose (beta = 1.03, 1.01-1.05, p = 0.008), daily SMBG %26gt;4 (beta = 1.06, 1.01-1.10, p = 0.01), severe hypoglycemia over the last year (beta = 1.06, 1.01-1.11, p = 0.02), lower numbers of diabetologic visits (beta = 1.07, 1.01-1.13, p = 0.02) and hypertension (beta = 1.06, 1.02-1.10, p = 0.005). Autonomic neuropathy was associated with diabetes impact. Female sex (beta = 4.36, 2.43-7.83) and daily SMBG %26gt;4 (beta = 3.77, 1.72-8.30) were independently associated with worst level and CSII with better level (beta = 0.22, 0.07- 0.68) of diabetes-related worries. %26lt;br%26gt;Conclusions: The impact of T1DM on QoL may depend on demographic, metabolic control-related variables, presence of complications and insulin delivery modality.

• 出版日期2013-10