A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax

作者：Brodszki Nicholas; Lan**erg John Kalle; Dictor Michael; Gyllstedt Erik; Ewers Sven Borje; Larsson Marcus K; Eklund Erik A^*

来源：Acta Paediatrica, 2011, 100(11): 1448-1453.

DOI：10.1111/j.1651-2227.2011.02361.x

• Acute respiratory failure
• Alpha-interferon therapy
• Heparin

Aim: To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective.
Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-alpha-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery.
Results: The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years.
Conclusion: The successful addition of a low anticoagulant, low molecular weight heparin ( tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.

• 出版日期2011-11