A simple and convenient synthesis of substituted furans and pyrroles by CuCl2-catalyzed heterocyclodehydration of 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols

作者：Gabriele Bartolo^*; Plastina Pierluigi; Vetere Mabel V; Veltri Lucia; Mancuso Raffaella; Salerno Giuseppe

来源：Tetrahedron Letters, 2010, 51(27): 3565-3567.

DOI：10.1016/j.tetlet.2010.05.001

• Copper
• Cyclization
• Heterocycles
• Furans
• Pyrroles

A simple and economical synthesis of substituted furans and pyrroles, by ligand-free CuCl2-catalyzed heterocyclodehydration of readily available 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols, respectively, is presented. Reactions are carried out in MeOH at 80-100 degrees C for 1-24 h and afford the corresponding heterocyclic derivatives in 53-99% isolated yields.

• 出版日期2010-7-7