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摘要
A new and simple method for synthesis of verbenachalcone (1) was reported. A method for reverse synthesis design was adopted to two synthetic fragments, compound 4 and compound 6. Then the two fragments were combined together, starting from p-hydroxybenzaldehyde(2) through acetylation, bromination, Ullmann reaction, methoxymethylation, aldol condensation, deprotection, catalytic hydrogenation seven steps to target compound, with total yield of 39.1%. The key steps were the Ullmann reaction of 3-bromo-4-hydroxybenzaldehyde (3) with vanilline. The chemical structures of the key intermediate and final target product were verified by (1)H NMR, (13)C NMR and ESI-MS.
- 出版日期2010-7-10
- 单位兰州理工大学
