Neural Signal Transmission Measurements with a Conductive Polymer Microelectrode Array

作者：Shimada Akiyoshi^*; Kasai Nahoko; Furukawa Yuriko; Nyberg Tobias; Torimitsu Keiichi

来源：Electrical Engineering in Japan, 2011, 177(1): 37-42.

DOI：10.1002/eej.21155

• conductive polymer
• microelectrode array
• neural network
• spike
• synaptic connection

The neural activity of dissociated cultures of mouse cortical neurons was measured with a conductive polymer microelectrode array. Each electrode was electrochemically polymerized from (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) and ethylenedioxythiophene on indium tin oxide electrodes. The spike activity of the cortical neurons was measured with the conducting polymer MEA and spike train cross-correlograms were calculated to predict the type of synaptic connection. Both excitatory and inhibitory synaptic connections were identified after 6 to 8 days in vitro. These results show that it is possible to determine the interaction between excitatory and inhibitory neurons in relation to information processing with this new polymer electrode.

• 出版日期2011-10