HMGB1: A new marker for estimation of the postmortem interval

作者：Kikuchi Kiyoshi; Kawahara Ko Ichi; Biswas Kamal Krishna; Ito Takashi; Tancharoen Salunya; Shiomi Naoto; Koda Yoshiro; Matsuda Fumiyo; Morimoto Yoko; Oyama Yoko; Takenouchi Kazunori; Miura Naoki; Arimura Noboru; Nawa Yuko; Arimura Shinichiro; Jie Meng Xiao; Shrestha Binita; Iwata Masahiro; Mera Kentaro; Sameshima Hisayo; Ohno Yoshiko; Maenosono Ryuichi; Tajima Yutaka; Uchikado Hisaaki; Kuramoto Terukazu; Nakayama Kenji; Shigemori Minoru; Yoshida Yoshihiro

来源：Experimental and Therapeutic Medicine, 2010, 1(1): 109-111.

DOI：10.3892/etm_00000019

• high
• mobility
• group box-1
• postmortem interval
• forensic medicine

Estimation of the postmortem interval (PMI) is one of the most important tasks in forensic medicine Numerous methods have been proposed for the determination of the time since death by chemical means High mobility group box-1 (HMGB1), a nonhistone DNA-binding protein is released by eukaryotic cells upon necrosis Postmortem serum levels of HMGB1 of 90 male Wistar rats stored at 4 14 and 24 degrees C since death were measured by enzyme-linked immunosorbent assay The serum HMGB1 level showed a time-dependent increase up to seven days at 4 degrees C At 14 degrees C, the HMGB1 level peaked at day 3, decreased at day 4, and then plateaued At 24 degrees C, the HMGB1 level peaked at day 2, decreased at day 3, and then plateaued Our findings suggest that HMGB1 is related to the PMI in rats

• 出版日期2010-2