Dopamine-assisted immobilization of hydroxyapatite nanoparticles and RGD peptides to improve the osteoconductivity of titanium

作者：Chien Chih Yuan; Liu Tse Ying; Kuo Wei Hsuan; Wang Meng Jiy; Tsai Wei Bor^*

来源：Journal of Biomedical Materials Research Part A, 2013, 101(3): 740-747.

DOI：10.1002/jbm.a.34376

• hydroxyapatite
• dopamine
• osteoblasts
• osteoconduction
• RGD

Hydroxyapatite (HAp) coating on orthopedic implants is a common strategy to increase osteointegration. In this work, a facile deposition method based on dopamine polymerization was developed for preparation of HAp-coated titanium substrates for orthopedic applications. Nanostructured HAp was mixed with an alkaline dopamine solution and then deposited onto titanium to form a dopamine/HAp ad-layer. The deposition of dopamine/HAp greatly enhanced the adhesion, proliferation, and mineralization of osteoblasts. Furthermore, RGD-containing peptides were immobilized to dopamine/HAp coated titanium and further enhanced cell adhesion and osteogenic differentiation. In conclusion, this facile dopamine-assisted surface modification method shows a great potential for orthopedic and dental applications.

• 出版日期2013-3