Angiopoietin 2 levels in serum and bronchial lavage fluids and their relationship with cancer stages in lung cancer patients

作者：Ayten Omer; Tas Dilaver^*; Demirer Ersin; Okutan Oguzhan; Ciftci Faruk; Aytekin Metin; Uysal Atilla; Kartaloglu Zafer

来源：Thoracic Cancer, 2013, 4(1): 20-26.

DOI：10.1111/j.1759-7714.2012.00128.x

• angiopoietin 2
• bronchial lavage fluid
• lung cancer
• metastasis
• tumor stage

Background: Angiopoietin 2 (Ang-2) has an important role in tumor angiogenesis. In this study, Ang-2 levels of serum and bronchioloalveolar lavage fluids (BALF) in patients with lung cancer were measured and correlated with clinical and biochemical parameters. Methods: Thirty-five cases newly diagnosed with lung cancer and 18 controls with non-cancerous lung diseases were included in the study. Tumor histology, staging, metastasis, tumor markers, biochemical and clinical parameters were all recorded. Results: Serum Ang-2 levels were significantly higher in the lung cancer group compared to the control (lung cancer median: 2.42ng/mL [2.192.98], control 0.67 [0.311.10]; P < 0.001), whereas Ang-2 levels in BALF were lower in the lung cancer group compared to the control (lung cancer median 0.41ng/mL [0.220.79], control 0.67 [0.461.03]; P = 0.02). In the cancer group, higher serum Ang-2 levels (r = 0.52, P < 0.001) were associated with the stage of cancer. No significant correlation was observed between BALF Ang-2 levels and non-small cell lung cancer stages and small-cell lung cancer advanced stage (P = 0.793, r = 0.07). Serum Ang-2 levels were significantly higher in distant metastasis (M1) versus no distant metastasis (M0) (M1: 2.57ng/mL [2.382.87], M0: 2.22 [1.492.40], P = 0.01). No significant correlation was observed between BALF Ang-2 levels and M1 (r = 0.11, P = 0.53). Conclusions: Serum Ang-2 levels were significantly higher in lung cancer patients and positive correlations were observed between serum Ang-2, tumor stage, and metastasis.

• 出版日期2013-2