Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus

作者：Yoon Sujung; Cho Hanbyul; Kim Jungyoon; Lee Do Wan; Kim Geon Ha; Hong Young Sun; Moon Sohyeon; Park Shinwon; Lee Sunho; Lee Suji; Bae Sujin; Simonson Donald C; Lyoo In Kyoon^*

来源：Diabetologia, 2017, 60(7): 1207-1217.

DOI：10.1007/s00125-017-4266-7

• Cognitive function
• Grey matter
• Obesity
• Overweight
• Type 2 diabetes mellitus
• White matter

Aims/hypothesis Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes.
Methods This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in their brain structures and cognition during early stage type 2 diabetes compared with participants with normal weight. Relationships between each of these measures and disease duration were also examined.
Results Global mean cortical thickness was lower in the overweight/obese type 2 diabetes group than in the normal-weight type 2 diabetes group (z = -2.96, p for group effect = 0.003). A negative correlation was observed between disease duration and global mean white matter integrity (z = 2.42, p for interaction = 0.02) in the overweight/obese type 2 diabetes group, but not in the normal-weight type 2 diabetes group. Overweight/obese individuals with type 2 diabetes showed a decrease in psychomotor speed performance related to disease duration (z = -2.12, p for interaction = 0.03), while normal-weight participants did not.
Conclusions/interpretation The current study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in brain structures and cognition during early stage type 2 diabetes compared with normal-weight participants.

• 出版日期2017-7