Association between human leukocyte antigen-G 14-bp insertion/deletion polymorphism and cancer risk: A meta-analysis and systematic review

作者：Ge, Yu-Zheng; Ge, Qian; Li, Ming-Hao; Shi, Guo-Mei; Xu, Xiao; Xu, Lu-Wei; Xu, Zheng; Lu, Tian-Ze; Wu, Ran; Zhou, Liu-Hua; Wu, Jian-Ping; Liang, Kai; Dou, Quan-Liang; Zhu, Jia-Geng; Li, Wen-Cheng; Jia, Rui-Peng^*

来源：Human Immunology, 2014, 75(8): 827-832.

DOI：10.1016/j.humimm.2014.06.004

• Human leukocyte antigen-G
• Polymorphism
• Cancer
• Meta-analysis

Background: Human leukocyte antigen-G (HLA-G) is involved in the development and progression of human cancers, and numerous molecular epidemiological studies have been conducted to explore the potential relationship of HLA-G 14-bp insertion/deletion (ins/del) polymorphism with cancer risk. However, results from published studies were inconclusive. @@@ Methods: Both PUBMED and EMBASE databases were searched comprehensively to identify eligible studies investigating the association of HLA-G 14-bp ins/del polymorphism with cancer risk. Statistical analysis was performed by using STATA 12.0 and Review Manager 5.0. @@@ Results: Fourteen eligible studies with 2340 cancer patients and 3967 controls were included and analyzed with odds ratio (OR) and its corresponding 95% confidence interval (CI). Overall, no significant association between HLA-G 14-bp ins/del polymorphism and overall cancer risk was detected in all comparison models. Further subgroup analyses based on ethnicity and cancer types demonstrated the significant association among Asians (ins/del vs. del/del: OR = 0.80, 95% CI, 0.66-0.95; ins/ins + ins/del vs. del/del: OR = 0.80, 95% CI, 0.65-0.97) and for breast cancer (ins allele vs. del allele: OR = 0.76, 95% CI, 0.61-0.96; ins/ins vs. del/del: OR = 0.57, 95% CI, 0.37-0.87; and ins/ins vs. ins/del + del/del: OR = 0.60, 95% CI, 0.42-0.87). @@@ Conclusion: This study suggested that HLA-G 14-bp ins/del polymorphism might contribute to breast cancer susceptibility and overall cancer risk among Asians. Further well-designed studies with larger sample size are warranted to validate our conclusion.

• 出版日期2014-8
• 单位中国人民武装警察部队总医院; 南京医科大学