An efficient Pd-catalyzed hydration of nitrile with acetaldoxime

作者：Kim Eun Sun; Kim Hoo Sook; Kim Jae Nyoung^*

来源：Tetrahedron Letters, 2009, 50(24): 2973-2975.

DOI：10.1016/j.tetlet.2009.04.007

• Palladium
• Nitrite
• Hydration
• Amide
• Acetaldoxime

An efficient palladium-catalyzed protocol for the hydration of nitrile to amide with acetaldoxime has been developed. A plausible mechanism was suggested involving the first Pd(II)-catalyzed nitrile-oxime coupling and the following disruption of the intermediate into amide and acetonitrile in a concerted manner.

• 出版日期2009-6-17