Association between auditory P300, psychopathology, and memory function in drug-naive schizophrenia

作者：Chang Wei Hung; Chen Kao Chin; Yang Yen Kuang; Chen Po See; Lu Ru Band; Yeh Tzung Lieh; Wang Carol Sheei Meei; Lee I Hui^*

来源：The Kaohsiung Journal of Medical Sciences, 2014, 30(3): 133-138.

DOI：10.1016/j.kjms.2013.10.003

• Default model network
• Drug-naive schizophrenia
• P300
• Psychopathology
• Visual memory

The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naive patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale-Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = -0.66, p < 0.05). Moreover, visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p < 0.05). After controlling for the duration of illness, the above correlations remained statistically significant. The correlation between P300 and the severity of psychopathology was reconfirmed in drug-naive patients with schizophrenia. A possible contribution of memory decompensation in P300 among drug-naive patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association.

• 出版日期2014-3