Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

作者：Izar Maria C^*; Fonseca Henrique A; Pinheiro Luiz F; Monteiro Carlos M; Povoa Rui M; Monteiro Andrea M; Figueiredo Neto Antonio M; Gidlund Magnus A; Fonseca Francisco A

来源：Diabetes and Vascular Disease Research, 2013, 10(1): 32-39.

DOI：10.1177/1479164112443374

• Acute coronary syndrome (ACS)
• autoantibodies (Abs)
• metabolic syndrome (MetS)
• oxidized low-density lipoprotein (oxLDL)

Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized low-density lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. The severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). In conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS.

• 出版日期2013-1