A Genome-wide Scan for Selective Sweeps in Racing Horses

作者：Moon Sunjin; Lee Jin Woo; Shin Donghyun; Shin Kwang Yun; Kim Jun; Choi Ik Young; Kim Jaemin; Kim Heebal^*

来源：Asian-Australasian Journal of Animal Sciences, 2015, 28(11): 1525-1531.

DOI：10.5713/ajas.14.0696

• Single Nucleotide Polymorphism
• Racehorse
• Selective Sweep
• Quantitative Trait Loci

Using next-generation sequencing, we conducted a genome-wide scan of selective sweeps associated with selection toward genetic improvement in Thoroughbreds. We investigated potential phenotypic consequence of putative candidate loci by candidate gene association mapping for the finishing time in 240 Thoroughbred horses. We found a significant association with the trait for Ral GApase alpha 2 (RALGAP2) that regulates a variety of cellular processes of signal trafficking. Neighboring genes around RALGAP2 included insulinoma-associated 1 (INSM1), pallid (PLDN), and Ras and Rab interactor 2 (RIN2) genes have similar roles in signal trafficking, suggesting that a co-evolving gene cluster located on the chromosome 22 is under strong artificial selection in racehorses.

• 出版日期2015-11