Meiosis: A PRDM9 Guide to the Hotspots of Recombination

作者:Hochwagen Andreas*; Marais Gabriel A B
来源:Current Biology, 2010, 20(6): R271-R274.
DOI:10.1016/j.cub.2010.01.048

摘要

During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.

  • 出版日期2010-3-23