A 1,5-benzothiazepine synthesis

作者：Phippen Christopher B W; McErlean Christopher S P^*

来源：Tetrahedron Letters, 2011, 52(13): 1490-1492.

DOI：10.1016/j.tetlet.2011.01.098

• Benzothiazepine
• Heterocyclic chemistry
• Aqueous chemistry
• N-Acylpyrrole

The pharmaceutically active compound (+/-)-thiazesim was synthesized in four steps and 62% overall yield. This new approach to biologically relevant benzothiazepine ring systems features the use of water as a solvent, co-solvent or catalyst in three of the four steps.

• 出版日期2011-3-30