Post-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation

作者：Grenzi Patricia C; Campos Erika F; Silva Helio T Jr; Felipe Claudia R; Franco Marcelo F; Soares Maria F; Medina Pestana Jose O; Gerbase DeLima Maria^*

来源：Transplant Immunology, 2015, 32(2): 61-65.

DOI：10.1016/j.trim.2015.02.004

• sCD30
• Subclinical rejection
• Kidney transplantation
• Post-transplant monitoring
• Protocol biopsy

Several studies have shown association of high pre- or post-transplant levels of soluble CD30 (sCD30) with acute rejection and poor late kidney transplant outcome. Our goal was to investigate whether sCD30 levels at month-3 post-transplant are associated with subclinical rejection, presence of CD30(+) cells within the graft, and expression of immune response genes in peripheral blood mononuclear cells. The study comprised 118 adult first kidney graft recipients, transplanted at a single center, receiving tacrolimus in low concentration. All were submitted to a protocol biopsy at month-3. Subclinical rejection was identified in 10 biopsies and sCD30 levels >= 61.88 ng/mL (P = 0.004), younger recipient age (P = 0.030) and non-Caucasian ethnicity (P = 0.011) were independently associated with this outcome. Rare CD30(+) cells were present in only two biopsies. There was a correlation between sCD30 levels and CD30 gene expression in peripheral blood mononuclear cells (r = 0.385, P = 0.043). These results show that high sCD30 levels are independent predictors of graft dysfunction and may contribute to patient selection protocols by indicating those who could benefit from a more thorough evaluation.

• 出版日期2015-3