An expedient synthesis of ellipticine via Suzuki-Miyaura coupling

作者：Konakahara Takeo^*; Kiran Y B; Okuno Yuri; Ikeda Reiko; Sakai Norio

来源：Tetrahedron Letters, 2010, 51(17): 2335-2338.

DOI：10.1016/j.tetlet.2010.02.125

• Ellipticine
• Suzuki-Miyaura coupling
• Formylation
• Steric sensitivity
• Double N-arylation

A simple and efficient total synthesis of ellipticine was developed via the Suzuki-Miyaura coupling of sterically sensitive 2-hytlroxybenzeneboronic acid with a multifunctional aryl halide using Pd(OAc)(2) as a catalyst and Cu(OAc)2 center dot H2O as an additive in DMSO/H2O as a key step followed by double N-arylation and cyclization.

• 出版日期2010-4-28