A Young Woman With Blurred Vision and Distal Paresthesias

作者:Kung Nathan H; Bartlett Nancy L; Yaseen Nabeel R; Van Stavern Gregory P; Bucelli Robert C*
来源:JAMA Neurology, 2015, 72(12): 1519-1523.
DOI:10.1001/jamaneurol.2015.2390

摘要

A 29-year-old woman presented with blurred vision and distal paresthesias. Her initial evaluation revealed severe bilateral optic disc edema with distal lower-extremity sensory and motor deficits and electrodiagnostic evidence of a length-dependent mixed demyelinating and axonal polyneuropathy. The results of routine diagnostic testing, including laboratory tests, magnetic resonance imaging, and lumbar puncture, were nondiagnostic. A targeted biopsy was ultimately required for diagnosis. In this article, we discuss the differential diagnosis and outline the clinical evaluation indicated for a patient presenting with demyelinating polyneuropathy and concurrent papilledema.

  • 出版日期2015-12

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