科研之友
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摘要
Capsaicin (CAP) and dihydrocapsaicin (DHC) are major pungent components of hot peppers with various biological activities such as anticancer, anti-obesity and anti-inflammatory properties. We focused on the involvement of heme oxygenase-1 (HO-1) in the anti-inflammatory activity of CAP and DHC in lipopolysaccaride (LPS)-stimulated RAW264.7 macrophages. We demonstrated that both CAP and DHC inhibited nitric oxide (NO) production and inducible NO synthase protein and mRNA expression in LPS-stimulated RAW264.7 macrophages. In addition, both CAP and DHC increased HO-1 protein expression. The inhibition of NO production by treatment with CAP and DHC was attenuated by blocking HO-1 activity. This study provide evidence to support the important role of HO-1 in the anti-inflammatory activity of CAP and DHC.
- 出版日期2014-8
