Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children

作者：Williams Dylan M; Fraser Abigail; Fraser William D; Hyppoenen Elina; Smith George Davey; Deanfield John; Hingorani Aroon; Sattar Naveed; Lawlor Debbie A^*

来源：Heart, 2013, 99(24): 1849-1856.

DOI：10.1136/heartjnl-2013-303678

• LIPIDS

Objective Lower maternal vitamin D status in pregnancy may be associated with increased offspring cardiovascular risk in later life, but evidence for this is scant. We examined associations of maternal total 25-hydroxyvitamin D (25(OH)D) in pregnancy with offspring cardiovascular risk factors assessed in childhood and adolescence. %26lt;br%26gt;Design A longitudinal, prospective study. %26lt;br%26gt;Setting The study was based on data from mother-offspring pairs in the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK prospective population-based birth cohort (N=4109). %26lt;br%26gt;Outcome measures Offspring cardiovascular risk factors were measured in childhood (mean age 9.9years) and in adolescence (mean age 15.4years): blood pressure, lipids, apolipoproteins (at 9.9years only), glucose and insulin (at 15.4years only), C reactive protein (CRP), and interleukin 6 (at 9.9years only) were measured. %26lt;br%26gt;Results After adjustments for potential confounders (maternal age, education, body mass index (BMI), smoking, physical activity, parity, socioeconomic position, ethnicity, and offspring gestational age at 25(OH)D sampling; gender, age, and BMI at outcome assessment), maternal 25(OH)D was inversely associated with systolic blood pressure (-0.48mmHg difference per 50nmol/L increase in 25(OH)D; 95% CI -0.95 to -0.01), Apo-B (-0.01mg/dL difference; 95% CI -0.02 to -0.001), and CRP (-6.1% difference; 95% CI -11.5% to -0.3%) at age 9.9years. These associations were not present for risk factors measured at 15.4years, with the exception of a weak inverse association with CRP (-5.5% difference; 95% CI -11.4% to 0.8%). There was no strong evidence of associations with offspring triglycerides, glucose or insulin. %26lt;br%26gt;Conclusions Our findings suggest that fetal exposure to 25(OH)D is unlikely to influence cardiovascular risk factors of individuals later in life.

• 出版日期2013-12-15