Uncoupling Protein 2 (UCP2) and p53 Expression in Invasive Ductal Carcinoma of Breast

作者：Won Kyu Yeoun; Kim Gou Young; Kim Youn Wha; Lim Sung Jig; Song Jeong Yoon^*

来源：Korean Journal of Pathology, 2010, 44(6): 565-570.

DOI：10.4132/KoreanJPathol.2010.44.6.565

• Carcinoma
• ductal
• breast
• Mitochondrial uncoupling protein 2
• Tumor suppressor protein p53
• Reactive oxygen species

Background : Uncoupling protein 2 (UCP2) is a recently identified mitochondrial inner membrane anion carrier and a negative regulator of reactive oxygen species production. In this study, we evaluated the characteristics and relationships of UCP2 and p53 expression in breast cancer tissues. Methods : Tissue microarray slides from 107 cases of invasive ductal carcinoma of the breast were constructed, UCP2 and p53 immunohistochemical staining was conducted, and clinicopathological correlations were investigated. Results : UCP2 expression in invasive ductal carcinoma was high in 53 cases (49.5%), while p53 expression in invasive ductal carcinoma was high in 37 cases (34.6%). UCP2 expression was correlated significantly with histological grade (p = 0.038) and mitotic count (p = 0.050). UCP2 expression was correlated significantly with p53 expression in invasive ductal carcinoma of the breast (p = 0.045). UCP2 expression (p = 0.8308) and p53 expression (p = 0.3292) showed no significant difference for the overall survival rate in patients with invasive ductal carcinoma. Conclusions : UCP2 expression in invasive ductal carcinoma increased proportionally with histological grade and mitotic count. High UCP2 expression in invasive ductal carcinoma was observed in conjunction with high p53 expression.

• 出版日期2010