科研之友
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摘要
Chronic persistent inflammation could play an. inflammation is a critical factor for bladder cancer important role in the pathogenesis of some malignancies, and development. In this study, we measured urine levels of transforming growth factor-alpha (TGF-alpha), tumor necrosis factor-alpha (TNF-alpha), and IL-8 in arsenic exposure workers and expressions o 'inflammatory cytoldnes in human urothelial cells in vivo and in vitro': We found the concentrations of IL-8, and ThGFha the presented in urine were significantly elevated in e.g urinary arsenic workers compared with the low urinary arsenic workers. Multiple;egression analysis showed that the urinary IL-8,TNF-alpha,TGF-o """,. IL-8 level was significantly positively associated with ker iAs concentration after adjusting for the confounding effects of age employed years; body maskixidex (BMI), smoking, alcohol, and seafood consumption in recent 3 days. Urin, TGF-alpha levels were also significantly positively associated with urinary iAs concentration, and SMI. TGF-a level was negatively associated With age after adjusting for the confounding effects. Consistent with the results in vivo, mRNA.expressions of TNF-a, TGF-alpha; ancrIL-8 and protein expressions of TGF-a, TGF-beta l, and IL-8 were significantly elevated in SV-HUC=1,cellS after exposure to lower concentrations of arsenite for 24h as compared to the control group. These data indicateac that arsenic increased the secretion of inflammatory factors and IL-8, TNF-alpha, and TGF-a expression may be a useful biomarker of the effect of arsenic exposure.
- 出版日期2014-11
- 单位中国医科大学
