Antibody-secreting plasma cells persist for decades in human intestine

作者：Landsverk Ole J B^*; Snir Omri; Casado Raquel Bartolome; Richter Lisa; Mold Jeff E; Reu Pedro; Horneland Rune; Paulsen Vemund; Yaqub Sheraz; Aandahl Einar Martin; Oyen Ole M; Thorarensen Hildur Sif; Salehpour Mehran; Possnert Goran; Frisen Jonas; Sollid Ludvig M; Baekkevold Espen S; Jahnsen Frode L^*

来源：Journal of Experimental Medicine, 2017, 214(2): 309-317.

DOI：10.1084/jem.20161590

Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19(+) PC subset was dynamically exchanged, whereas of two CD19(-) PC subsets, CD45(+) PCs exhibited little and CD45(-) PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45(-) PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19(-) PC subsets support selection and maintenance of protective PCs for life in human intestine.

• 出版日期2017-2