DOUBLE INTRAMOLECULAR 1,3-DIPOLAR CYCLOADDITION OF DIAZIDO-TERMINAL DIALKYNE: SYNTHESIS OF A NEW BIS(1,2,3-TRIAZOLO-1,4-OXAZINE)

作者：Mekni Nejib Husein^*; Baklouti Ahmed

来源：Heterocycles, 2012, 85(7): 1727-+.

DOI：10.3987/COM-12-12516

• Intramolecular Double Cycloaddition
• Click Chemistry
• 1,3-Dipolar Double Cycloaddition
• Tetracyclic Compound
• Bis(1,2,3-triazolo-1,4-oxazine)

A new bis(1,2,3-triazolo-1,4-oxazine) fused heterocyclic compound was synthesized from terminal meso-1,2,3,4-diepoxybutane via azide ring opening reaction, followed by propargylation and double 1,3-dipolar intramolecular cycloaddition. No effect on the reaction outcome was observed when Cu(I) was used as catalyst. In both cases catalyzed and uncatalyzed reactions, only the exo-tetracyclic two to two fused isomer was obtained.

• 出版日期2012-7-1