Alkylation of Oxazolones and Related Heterocycles through an S(N)1 Reaction

作者:Alba Andrea Nekane R; Calbet Teresa; Font Bardia Merce; Moyano Albert; Rios Ramon*
来源:European Journal of Organic Chemistry, 2011, 2011(11): 2053-2056.
DOI:10.1002/ejoc.201100046

摘要

The alkylation of oxazolones through an S(N)1 reaction by using stabilized carbocations is reported. The reaction (catalyzed by Bronsted acids, such as TFA or thioureas) affords the final compounds in excellent yields. Reaction with other heterocycles has also been studied, rendering pyrazolone or oxindole derivatives in good yields.

  • 出版日期2011-4