Development and Validation of UV Spectrophotometric Method to Study Stress Degradation Behaviour of Rizatriptan Benzoate

作者：Amolkumar Kempwade^*; Ashok Tar****li; Kiran Jadhav

来源：Spectroscopy and Spectral Analysis, 2015, 35(1): 137-140.

DOI：10.3964/j.issn.1000-0593(2015)01-0137-04

• Rizatriptan benzoate
• UV spectroscopy
• Stress degradation
• Validation

Rizatriptan benzoate is a 5 HT 1B/1D receptor agonist which is prescribed for the treatment of migraine. In the present study new, simple, specific ultraviolet spectrophotometric method for rizatriptan benzoate was developed and validated. Forced degradation studies were carried out in acidic, alkaline and neutral pH conditions. The absorbance maxima peak was found to be 224 nm and linearity was observed in the concentration range of 0. 5 similar to 2. 5 mu g center dot mL(-1) with regression coefficient value of 0. 998 8. The method was validated and found to be precise. The percent recovery for rizatriptan benzoate was found to be 98. 576 +/- 0. 202. The bulk drug was found to be stable in neutral and acidic pH conditions but got degraded in 1 N NaOH solution.

• 出版日期2015-1