HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus

作者：Carrozzo M^*; Elia A; Mereu V; Dametto E; Fasano M E; Broccoletti R; Rendine S; Amoroso A

来源：Oral Diseases, 2011, 17(3): 309-313.

DOI：10.1111/j.1601-0825.2010.01742.x

• killer cell immunoglobulin-like receptor
• hepatitis C
• virus
• oral lichen planus

Objectives:
Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft-versus-host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin-like receptor (KIR) genes encode a family of receptors expressed on NK and T cells and are supposed to play a significant role in GVHD and HCV infection. The aim of this study was to analyze the association among OLP, HCV infection and variants in KIR gene expression.
Methods:
A total of 81 patients with OLP (36 HCV+ve and 45 HCV-ve) and 217 healthy controls (HCV-ve) were typed for the presence of eight KIR genes and of HLA-Cw* alleles by polymerase chain reaction-sequence specific primer.
Results:
There were no significant differences in the frequency of the KIR genes and HLA-C1/C2 group alleles between cases and controls. We only found a significant difference in the frequency of the gene KIR2DL2 between HCV+ve and HCV-ve OLP patients.
Conclusions:
The present data suggest that OLP is not associated with particular KIR genes or with HLA-Cw* alleles in patients without HCV infection. Contrarily, the role of the genes in OLP-HCV+ve patients remains unclear and might warrant further researches.

• 出版日期2011-4