ASSOCIATION BETWEEN-41657C/T SINGLE NUCLEOTIDE POLYMORPHISM OF DNA REPAIR GENE XRCC2 AND ENDOMETRIAL CANCER RISK IN POLISH WOMEN

作者：Michalska Magdalena M; Samulak Dariusz; Bienkiewicz Jan; Romanowicz Hanna; Smolarz Beata^*

来源：Polish Journal of Pathology, 2015, 66(1): 67-71.

DOI：10.5114/PJP.2015.51155

• endometrial cancer
• XRCC2 gene
• genetic polymorphism

Aim of the study: The XRCC2 gene plays a crucial role in double-strand DNA break repair by homologous recombination. Current literature provides clear evidence that XRCC2 polymorphisms may be associated with the development of certain types of cancer; however, still little is known about their association with endometrial cancer (EC).
Material and methods: The single nucleotide polymorphism (SNP) -41657C/T (rs718282) of the XRCC2 gene was investigated by PCR-RFLP in 304 patients with EC and in 200 age- and sex-matched non-cancer controls.
Results: The analysis revealed a relationship between XRCC2 -41657C/T polymorphism and the incidence of EC. Endometrial cancer patients showed over-representation of the T allele of the SNP. The T/T homozygous variant increased the cancer risk. There were no significant differences between the distribution of XRCC2 -41657C/T genotypes in the subgroups according to histological grade.
Conclusions: This is the first study that links the SNP -41657C/T (rs718282) of the XRCC2 gene with EC in Polish women. The results support the hypothesis that this polymorphism may be positively correlated with the incidence of EC.

• 出版日期2015-3