Applications of biomaterials in corneal wound healing

作者：Tsai I Lun; Hsu Chih Chien; Hung Kuo Hsuan; Chang Chi Wen; Cheng Yung Hsin^*

来源：Journal of the Chinese Medical Association, 2015, 78(4): 212-217.

DOI：10.1016/j.jcma.2014.09.011

• bioengineered prosthetic devices
• biomaterials
• contact lenses
• corneal regeneration
• hydrogels

Disease affecting the cornea is a common cause of blindness worldwide. To date, the amniotic membrane (AM) is the most widely used clinical method for cornea regeneration. However, donor-dependent differences in the AM may result in variable clinical outcomes. To overcome this issue, biomaterials are currently under investigation for corneal regeneration in vitro and in vivo. In this article, we highlight the recent advances in hydrogels, bioengineered prosthetic devices, contact lenses, and drug delivery systems for corneal regeneration. In clinical studies, the therapeutic effects of biomaterials, including fibrin and collagen-based hydrogels and silicone contact lenses, have been demonstrated in damaged cornea. The combination of cells and biomaterials may provide potential treatment in corneal wound healing in the future.

• 出版日期2015-4
• 单位长春大学