A Highly Regio- and Diastereoselective Phosphane-Catalyzed [3+2] Annulation of Morita-Baylis-Hillman Carbonates with Cyclic N-Acyl Ketimines

作者：Yang Li Jun; Cai Hua; Nie Jing; Ma Jun An^*

来源：European Journal of Organic Chemistry, 2013, 2013(20): 4434-4442.

DOI：10.1002/ejoc.201300342

• Synthetic methods
• Nitrogen heterocycles
• Annulation
• Phosphorus
• Diastereoselectivity
• Asymmetric catalysis

A highly regio- and diastereoselective phosphane-catalyzed [3+2] annulation of Morita-Baylis-Hillman (MBH) carbonates with cyclic N-acyl-substituted ketimines was developed. In the presence of the catalyst PBu3 (10 mol-%), a series of N-fused tricyclic products were obtained in excellent yields and diastereoselectivities under mild conditions. An example of a catalytic enantioselective annulation is also presented.

• 出版日期2013-7
• 单位天津大学