科研之友
微信
新浪微博
Facebook
分享链接
摘要
Notch signaling plays multiple roles in T cell development. Following thymic entry. Notch signals are required to specify the T cell fate from a multipotent hematopoietic progenitor. At subsequent steps in early T cell development, Notch provides important differentiation, survival, proliferation and metabolic signals. This review focuses on the multiple functions of Notch in early T cell development, from T cell specification in the thymus through beta selection.
- 出版日期2010-10
