Spaceflight-relevant types of ionizing radiation and cortical bone: Potential LET effect?

作者：Lloyd Shane A J; Bandstra Eric R; Travis Neil D; Nelson Gregory A; Bourland J Daniel; Pecaut Michael J; Gridley Daila S; Willey Jeffrey S; Bateman Ted A^*

来源：Advances in Space Research, 2008, 42(12): 1889-1897.

DOI：10.1016/j.asr.2008.08.006

• Radiation
• Spaceflight
• Cortical bone
• Bone loss
• Microcomputed tomography

Extended exposure to microgravity conditions results in significant bone loss. Coupled with radiation exposure, this phenomenon may place astronauts at a greater risk for mission-critical fractures. In a previous study, we identified a profound and prolonged loss of trabecular bone (29-39%) in mice following exposure to an acute, 2 Gy dose of radiation simulating both solar and cosmic sources. However, because skeletal strength depends oil trabecular and cortical bone, accurate assessment of strength requires analysis of both bone compartments. The objective of the present Study wits to examine various properties of cortical bone in Mice following exposure to multiple types of spaceflight-relevant radiation. Nine-week old, female C57BL/6 mice were sacrificed 110 days after exposure to a single, whole body, 2 Gy dose of gamma, proton, carbon, or iron radiation. Femora were evaluated with biomechanical testing, microcomputed tomography, quantitative histomorphometry, percent mineral content, and micro-hardness analysis. Compared to non-irradiated controls, there were significant differences compared to carbon or iron radiation for only fracture force, medullary area and mineral content. A greater differential effect based oil linear energy transfer (LET) level may be present: high-LET (carbon or iron) particle irradiation was associated with a decline in structural properties (maximum force, fracture force, medullary area, and cortical porosity) and mineral composition compared to low-LET radiation (gamma and proton). Bone loss following irradiation appears to be largely specific to trabecular bone and may indicate unique biological microenvironments and microdosimetry conditions. However, the limited time points examined and non-haversian skeletal structure of the mice employed highlight the need for further investigation.

• 出版日期2008-12-15