科研之友
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摘要
In an attempt to construct 10-acyl-5H-benzo[e]pyrrolo[1,2-a]azepines-via acid-catalyzed intramolecular alkyne carbonyl metathesis, two distinctive modes of cyclization were revealed to depend on the reaction temperatures. 5H-Benzo [e]pyrrolo [1,2-a] azepine-1-carb aldehydes with a substituent at the C11 position were obtained as major products at 90 degrees C as a result of intramolecular 7-endo-dig 40 degrees C cyclization, while 6-endo-dig ring closure by electrophilic addition of nitrogen of the pyrrole to a vinyl cation generated under acidic medium followed by an unprecedented domino rearrangement process was observed at 40 degrees C in some cases, resulting in 5-aryl-11H-benzo[d]pyrrolo[1,2-a]azepine-1-carbaldehydes along with the former products.
- 出版日期2017-3-17
