科研之友
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摘要
Physical mapping is a useful approach for studying genome organization and evolution as well as for genomc sequence assembly The availability of polytene chromosomes in malaria mosquitoes provides a unique opportunity to develop high resolution physical maps We report a 0 6 Mb resolution physical map consisting of 422 DNA markers hybridized to 379 chromosomal sites of the Anopheles stephensi polytene chromosomes This makes An stephensi second only to Anopheles gambiae in density of a physical map among malaria mosquitoes Three hundred sixty three (363) probes hybridized to single chromosomal sites where as 59 clones yielded multiple signals This physical map provided a suitable basis for comparative genomics which was used for determining inversion breakpoints duplications and origin of novel genes across species
- 出版日期2010-11
- 单位Virginia Tech; 美国弗吉尼亚理工大学(Virginia Tech)
