A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis

作者：Chung, Yu-Ming; Chang, Fang-Rong; Tseng, Tseng-Fu; Hwang, Tsong-Long; Chen, Lei-Chin; Wu, Shou-Fang; Lee, Chia-Lin; Lin, Zu-Yau; Chuang, Li-Yeh; Su, Jinu-Huang^*; Wu, Yang-Chang

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(6): 1792-1794.

DOI：10.1016/j.bmcl.2011.01.067

• Aristolochia manshuriensis
• Aristopyridinone A
• Aristolamide II
• Phenanthrene
• Anti-inflammatory
• Human neutrophils
• Superoxide anion
• Elastase release

A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC50 value of 4.11 mu g/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 mu g/mL, respectively.

• 出版日期2011-3-15
• 单位中山大学; 长春大学; 中国医科大学