Aortic Regurgitation Index Defines Severity of Peri-Prosthetic Regurgitation and Predicts Outcome in Patients After Transcatheter Aortic Valve Implantation

作者：Sinning, Jan-Malte; Hammerstingl, Christoph; Vasa-Nicotera, Mariuca; Adenauer, Viktoria; Cachiguango, Sisa Josefina Lema; Scheer, Anne-Catherine; Hausen, Sven; Sedaghat, Alexander; Ghanem, Alexander; Mueller, Cornelius; Grube, Eberhard; Nickenig, Georg^*; Werner, Nikos

来源：Journal of the American College of Cardiology, 2012, 59(13): 1134-1141.

DOI：10.1016/j.jacc.2011.11.048

• AR index
• CoreValve
• paravalvular leak
• periprosthetic regurgitation
• TAVI

Objectives The aim of this study was to provide a simple, reproducible, and point-of-care assessment of peri-prosthetic aortic regurgitation (periAR) during transcatheter aortic valve implantation (TAVI) and to decipher the impact of this peri-procedural parameter on outcome. @@@ Background Because periAR after TAVI might be associated with adverse outcome, precise quantification of periAR is of paramount importance but remains technically challenging. @@@ Methods The severity of periAR was prospectively evaluated in 146 patients treated with the Medtronic CoreValve (Minneapolis, Minnesota) prosthesis by echocardiography, angiography, and measurement of the aortic regurgitation (AR) index, which is calculated as ratio of the gradient between diastolic blood pressure (DBP) and left ventricular end-diastolic pressure (LVEDP) to systolic blood pressure (SBP): [(DBP - LVEDP)/SBP] x 100. @@@ Results After TAVI, 53 patients (36.3%) showed no signs of periAR and 71 patients (48.6%) showed only mild periAR, whereas 18 patients (12.3%) and 4 patients (2.7%) suffered from moderate and severe periAR, respectively. The AR index decreased stepwise from 31.7 +/- 10.4 in patients without periAR, to 28.0 +/- 8.5 with mild periAR, 19.6 +/- 7.6 with moderate periAR, and 7.6 +/- 2.6 with severe periAR (p < 0.001), respectively. Patients with AR index <25 had a significantly increased 1-year mortality risk compared with patients with AR index >= 25 (46.0% vs. 16.7%; p < 0.001). The AR index provided additional prognostic information beyond the echocardiographically assessed severity of periAR and independently predicted 1-year mortality (hazard ratio: 2.9, 95% confidence interval: 1.3 to 6.4; p = 0.009). @@@ Conclusions The assessment of the AR index allows a precise judgment of periAR, independently predicts 1-year mortality after TAVI, and provides additional prognostic information that is complementary to the echocardiographically assessed severity of periAR.

• 出版日期2012-3-27