Association between urinary vascular endothelial growth factor excretion and chronic kidney disease in hyperthyroid cats

作者：Williams T L^*; Elliott J; Syme H M

来源：Research in Veterinary Science, 2014, 96(3): 436-441.

DOI：10.1016/j.rvsc.2014.02.011

• hypoxia
• PRA
• NAG
• RAAS
• proteinuria
• azotaemia

Many hyperthyroid cats develop azotaemic chronic kidney disease (aCKD) following treatment, which has led to the hypothesis that hyperthyroidism might be detrimental to renal function. Reninangiotensin-aldosterone system (RAAS) activation occurs in hyperthyroidism, which could cause pentubular hypoxia, tubular damage and the development of aCKD. Urinary vascular endothelial growth factor:creatinine ratio (VEGFCR) is postulated to be a marker of tubular hypoxia. VEGFCR was correlated with plasma renin activity (PRA) and compared between hyperthyroid cats that did and did not develop aCKD following treatment (pre-azotaemic and non-azotaemic groups respectively). PRA was positively correlated with VEGFCR (r(s) = 0.382; P = 0.028); however, pre-azotaemic hyperthyroid cats had significantly lower VEGFCR than non-azotaemic cats at baseline (median 122.3 fg/g versus 167.0 fg/g; P <0.001). RAAS activation in hyperthyroidism is associated with increased VEGFCR; however, increased VEGFCR was not correlated with the development of aCKD. Therefore, tubular hypoxia may not be a mechanism for renal damage in hyperthyroid cats.

• 出版日期2014-6