Novel fluorene-based supramolecular sensor for selective detection of amoxicillin in water and blood

作者：Shah Kiramat^*; Hassan Erum; Ahmed Farid; Anis Itrat; Rabnawaz Muhammad; Shah Muhammad Raza^*

来源：Ecotoxicology and Environmental Safety, 2017, 141: 25-29.

DOI：10.1016/j.ecoenv.2017.03.003

• Fluorescence spectroscopy
• Molecular recognition
• Supramolecular hosts
• Amoxicillin

Synthesis, characterization and molecular recognition properties of fluorene based supramolecular cleft 1 is reported. The cleft molecule 1 was prepared in a single-step with good yield (85% yield), by linking Fluorene with 1-ethyl piperazine. The cleft molecule 1 was carefully characterized using various spectroscopic techniques such as NMR and mass spectrometry. The supramolecular interaction of cleft 1 with amoxicillin, 6APA, aspirin, captopril, cefotaxime, ceftriaxone, cefuroxime, diclofenac, penicillin, and cephradine was evaluated by fluorescent spectroscopy. The molecular recognition studies showed that amoxicillin selectively binds with cleft 1 in the presence of other drugs. The analytical method developed for the supramolecular interaction of molecular cleft 1 and amoxicillin was validated at varying pH, concentration and temperature during recognition process. Job's plots indicated that the stochiometry of the interactions between the cleft 1 and the amoxicillin was 1:1.

• 出版日期2017-7